Unfortunately, measuring analog signals with a data acquisition device is not always as simple as wiring the signal source leads to the data acquisition device. Knowledge of the nature of the signal source, a suitable configuration of the data acquisition device, and an appropriate cabling scheme may be required to produce accurate and noise-free measurements. The integrity of the acquired data depends upon the entire analog signal path. In order to cover a wide variety of applications, most data acquisition devices provide some flexibility in their analog input stage configuration. The price of this flexibility is, however, some confusion as to the proper applications of the various input configurations and their relative merits. This note helps clarify the types of input configurations available on data acquisition devices, explains how the user should choose and use the configuration best for the application, and discusses interference noise pick up mechanisms and how to minimize interference noise by proper cabling and shielding. An understanding of the types of signal sources and measurement systems is a prerequisite to application of good measurement techniques, so we will begin by discussing the same.